Study People With Depression May Not Adapt As Well To Stress
The researchers identified a biomarker, or a medical sign, that indicates resilience to chronic stress in the brain. People with major depressive disorder were lacking that marker—which only led to further pessimism in daily life. Participants were asked to partake in repeated stressors. In people without depression, the marker glutamate spiked in response to stress. People with major depressive disorder lacked a response entirely. “Despite repeated stressors that suggests to us that perhaps the individual’s ability to respond to those stressors, is going to be lower if they are depressed, than if they are not depressed,” Melissa Shepard, MD, a psychiatrist based in Baltimore who was not involved in the study, tells Verywell....